Public research index

Evidence library for recovery and resilience research.

A public bibliography organized by compound group, study domain, source record, and available open documents. The library supports research question design, documentation review, and protocol development.

42 indexed literature records

14 compound or pathway groups

32 open PDFs or full-text records

42 official source links

Library standards

Public, source-linked, and organized by research question.

Entries are included for relevance to mechanism, tolerability, biomarkers, functional outcomes, or study design. Inclusion in the library is not a statement that a treatment effect is established.

Traceability

Official source first

Every record links to a DOI, PubMed, PMC, or publisher source so reviewers can verify the document trail.

Access

Open documents where available

Open PDFs and full-text records are surfaced directly. Metadata-only records link out to their official source.

Scope

Research design, not claims

The literature is organized around hypotheses, outcome domains, and quality review rather than commercial product claims.

Indexed literature

Compound-group bibliography.

Use the index below to scan the public document set by compound group and research domain.

Retatrutide ARA-290 Cibinetide Semax SS-31 Elamipretide BPC-157 TB-500 Thymosin Beta-4 Selank NAD+ MOTS-c Glutathione Thymosin Alpha-1 KPV GHK-Cu DSIP

Metabolic resilience

Retatrutide

3 literature records

Triple–Hormone-Receptor Agonist Retatrutide for Obesity

Jastreboff et al. . New England Journal of Medicine , 2023

Record 1

Clinical / human literature DOI / publisher record DOI 10.1056/NEJMoa2301972

Official Source

Efficacy and safety of retatrutide, a GIP, GLP-1, and glucagon receptor agonist, in people with type 2 diabetes and inadequate glycaemic control with diet and exercise (TRANSCEND-T2D-1)

Bajaj et al. . Lancet , 2026

Record 2

Clinical / human literature PubMed record PMID 42250575

Official Source

Triple hormone receptor agonist retatrutide for metabolic dysfunction-associated steatotic liver disease: a randomized phase 2a trial

Sanyal et al. . Nature Medicine , 2024

Record 3

Clinical / human literature Open full text and PDF PMC11271400 PMID 38858523

Open PDF Full Text HTML Official Source

Neuroprotection and neuropathic burden

ARA-290 Cibinetide

3 literature records

Safety and Efficacy of ARA 290 in Sarcoidosis Patients with Symptoms of Small Fiber Neuropathy: A Randomized, Double-Blind Pilot Study

Heij et al. . Molecular Medicine , 2012

Record 1

Clinical / human literature Open PDF available PMC3563705

Open PDF Official Source

ARA 290 Improves Symptoms in Patients with Sarcoidosis-Associated Small Nerve Fiber Loss and Neuropathic Pain: Results of a Pilot Study

Dahan et al. . Molecular Medicine , 2013

Record 2

Clinical / human literature Open PDF available PMC3883966

Open PDF Official Source

ARA 290, a Nonerythropoietic Peptide Engineered from Erythropoietin, Improves Metabolic Control and Neuropathic Symptoms in Patients with Type 2 Diabetes

Brines et al. . Molecular Medicine , 2015

Record 3

Clinical / human literature Open full text and PDF PMC4365069

Open PDF Full Text HTML Official Source

Cognitive readiness

Semax

3 literature records

Effects of Semax on the Default Mode Network of the Brain

Lebedeva et al. . Bulletin of Experimental Biology and Medicine , 2018

Record 1

Mechanistic literature DOI / publisher record DOI 10.1007/s10517-018-4234-3 PMID 30225715

Official Source

The peptide Semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis

Medvedeva et al. . BMC Genomics , 2014

Record 2

Preclinical / mechanistic literature Open PDF available PMC3987924 PMID 24661604

Open PDF Official Source

Semax, synthetic ACTH(4-10) analogue, attenuates ischemia-reperfusion-induced damage in rats

Glazova et al. , 2021

Record 3

Preclinical / mechanistic literature PubMed record PMID 33418449

Official Source

Mitochondrial resilience

SS-31 Elamipretide

3 literature records

Randomized dose-escalation trial of elamipretide in adults with primary mitochondrial myopathy

Karaa et al. . Neurology , 2018

Record 1

Clinical / human literature Open PDF available PMC5890606 PMID 29500292

Open PDF Official Source

Efficacy and Safety of Elamipretide in Individuals With Primary Mitochondrial Myopathy: The MMPOWER-3 Randomized Clinical Trial

Karaa et al. . Neurology , 2023

Record 2

Clinical / human literature Open PDF available PMC10382259 PMID 37268435

Open PDF Official Source

In vivo mitochondrial ATP production is improved in older adults following a single dose of elamipretide in a randomized trial

Roshanravan et al. . Nature Communications , 2021

Record 3

Clinical / human literature Open PDF available PMC8282018

Open PDF Official Source

Physical recovery and tissue repair

BPC-157

3 literature records

Pentadecapeptide BPC 157 Enhances the Growth Hormone Receptor Expression in Tendon Fibroblasts

Chang et al. . Molecules , 2014

Record 1

Preclinical / mechanistic literature Open PDF available PMC6271067 PMID 25415472

Open PDF Official Source

The anti-nociceptive effect of BPC-157 on the incisional pain model in rats

Jung et al. . Journal of Dental Anesthesia and Pain Medicine , 2022

Record 2

Preclinical / mechanistic literature Open PDF available PMC8995671 PMID 35449779

Open PDF Official Source

Stable Gastric Pentadecapeptide BPC 157 as Therapy After Quadriceps Muscle-to-Bone Detachment and Reattachment

Matek et al. . Biomedicines , 2025

Record 3

Preclinical / mechanistic literature Open full text and PDF PMC11768438

Open PDF Full Text HTML Official Source

Tissue remodeling and neurorecovery

TB-500 Thymosin Beta-4

3 literature records

Neuroprotective and neurorestorative effects of thymosin β4 treatment initiated 6 hours after traumatic brain injury

Xiong et al. . Annals of the New York Academy of Sciences , 2012

Record 1

Preclinical / mechanistic literature Open full text and PDF PMC3547647 PMID 23050817

Open PDF Full Text HTML Official Source

Thymosin beta 4 suppression of corneal NFκB: possible anti-inflammatory effect of a corneal wound-healing agent

Sosne et al. . Experimental Eye Research , 2007

Record 2

Preclinical / mechanistic literature Open full text and PDF PMC2211446

Open PDF Full Text HTML Official Source

Biological activities of thymosin β4 defined by active sites in short peptide sequences

Sosne et al. . FASEB Journal , 2010

Record 3

Mechanistic literature PubMed record PMID 20179146

Official Source

Stress regulation

Selank

3 literature records

A comparison of the anxiolytic effect and tolerability of selank and phenazepam in the treatment of anxiety disorders

Medvedev et al. . Zh Nevrol Psikhiatr Im S S Korsakova , 2014

Record 1

Clinical / human literature PubMed record PMID 25176261

Official Source

Immunomodulatory effects of selank in patients with anxiety-asthenic disorders

Uchakina et al. . Bulletin of Experimental Biology and Medicine , 2008

Record 2

Clinical / human literature PubMed record PMID 18577961

Official Source

Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats

Kasian et al. . Behavioural Neurology , 2017

Record 3

Preclinical / mechanistic literature Open PDF available PMC5322660 PMID 28280289

Open PDF Official Source

Cellular energy and behavioral recovery factors

NAD+

3 literature records

Intravenous infusion of nicotinamide adenine dinucleotide and nicotinamide riboside: a comparison of direct pharmacokinetic profiles, safety, and tolerability in humans

Reyna et al. . Aging Cell , 2026

Record 1

Clinical / human literature Open full text and PDF PMC12907335

Open PDF Full Text HTML Official Source

A Pilot Study Investigating Changes in the Human Plasma and Urine NAD+ Metabolome During a 6 Hour Intravenous Infusion of NAD+

Grant et al. . Frontiers in Aging Neuroscience , 2019

Record 2

Clinical / human literature Open PDF available DOI 10.3389/fnagi.2019.00257 PMID 31572171

Open PDF Official Source

Nicotinamide Adenine Dinucleotide (NAD+) and Enkephalinase Inhibitor Infusions Significantly Attenuate Psychiatric Burden Sequalae in Substance Use Disorder

Blum et al. . Journal of Personalized Medicine , 2022

Record 3

Mechanistic literature Open full text and PDF PMC9474872 PMID 36118157

Open PDF Full Text HTML Official Source

Mitochondrial stress and exercise tolerance

MOTS-c

3 literature records

MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis

Reynolds et al. . Nature Communications , 2021

Record 1

Mechanistic literature Open full text and PDF PMC7817689 PMID 33473109

Open PDF Full Text HTML Official Source

MOTS-c increases in skeletal muscle following long-term physical activity and improves acute exercise performance after a single dose

Hyatt et al. . FASEB Journal , 2022

Record 2

Mechanistic literature Open full text and PDF PMC9270643

Open PDF Full Text HTML Official Source

MOTS-c Serum Concentration Positively Correlates with Muscle Strength and Power in Healthy Young Men

Domin et al. . Medicina , 2023

Record 3

Clinical / human literature Open full text and PDF PMC10573682

Open PDF Full Text HTML Official Source

Oxidative burden and liver markers

Glutathione

3 literature records

Effects of Oral Glutathione Supplementation on Systemic Oxidative Stress Biomarkers in Human Volunteers

Allen et al. . Journal of Alternative and Complementary Medicine , 2011

Record 1

Clinical / human literature Open PDF available PMC3162377

Open PDF Official Source

Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function

Sinha et al. . European Journal of Clinical Nutrition , 2018

Record 2

Clinical / human literature Open full text and PDF PMC6389332

Open PDF Full Text HTML Official Source

Efficacy of glutathione for the treatment of nonalcoholic fatty liver disease

Honda et al. . BMC Gastroenterology , 2017

Record 3

Clinical / human literature Open full text and PDF PMC5549431 PMID 28789631

Open PDF Full Text HTML Official Source

Immune modulation

Thymosin Alpha-1

3 literature records

The efficacy and safety of thymosin α1 for sepsis (TESTS): a multicentre, randomised placebo-controlled trial

Wu et al. . BMJ , 2025

Record 1

Clinical / human literature Open PDF available PMC11780596

Open PDF Official Source

Thymosin alpha 1 restores the immune homeostasis in lymphocytes during Post-Acute sequelae of SARS-CoV-2 infection

Minutolo et al. . International Immunopharmacology , 2023

Record 2

Clinical / human literature Open full text and PDF PMC10030336

Open PDF Full Text HTML Official Source

A Double-blind Multicenter Two-arm Randomized Placebo-controlled Phase-III Clinical Study to Evaluate the Effectiveness and Safety of Thymosin α1 as an Add-on Treatment to Existing Standard of Care Treatment in Moderate-to-severe COVID-19 Patients

Shetty et al. . Indian Journal of Critical Care Medicine , 2022

Record 3

Clinical / human literature Open PDF available PMC9363815 PMID 36042753

Open PDF Official Source

Inflammation and gut barrier research

KPV

3 literature records

PepT1-Mediated Tripeptide KPV Uptake Reduces Intestinal Inflammation

Dalmasso et al. . Gastroenterology , 2008

Record 1

Mechanistic literature Open full text and PDF PMC2431115 PMID 18061177

Open PDF Full Text HTML Official Source

Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis

Xiao et al. . Molecular Therapy , 2017

Record 2

Preclinical / mechanistic literature Open full text and PDF PMC5498804

Open PDF Full Text HTML Official Source

Inflammation-triggered self-immolative conjugates enable oral delivery of the therapeutic tripeptide KPV to treat inflammatory bowel disease and lung inflammation

Cheng et al. . Nature Communications , 2026

Record 3

Mechanistic literature Open full text and PDF PMC12802832

Open PDF Full Text HTML Official Source

Wound repair and cognitive resilience

GHK-Cu

3 literature records

Intranasal GHK peptide enhances resilience to cognitive decline in 5xFAD transgenic mice

Tucker et al. . Experimental Gerontology , 2023

Record 1

Preclinical / mechanistic literature Open PDF available PMC10680828 PMID 38014118

Open PDF Official Source

The tri-peptide GHK-Cu complex ameliorates lipopolysaccharide-induced acute lung injury in mice

Park et al. . Oncotarget , 2016

Record 2

Preclinical / mechanistic literature Open full text and PDF PMC5295439 PMID 27517151

Open PDF Full Text HTML Official Source

In Vitro and in Vivo Studies of pH-Sensitive GHK-Cu Peptide-Loaded Hydrogels for Wound Healing Applications

Sharma et al. . Biomedicines , 2019

Record 3

Preclinical / mechanistic literature Open full text and PDF PMC6893953

Open PDF Full Text HTML Official Source

Sleep and withdrawal literature

DSIP

3 literature records

Effects of delta sleep-inducing peptide on sleep of chronic insomniacs

Bes et al. . Sleep , 1992

Record 1

Clinical / human literature PubMed record PMID 1299794

Official Source

DSIP in the treatment of withdrawal syndromes from alcohol and opiates

Dick et al. . Progress in Neuro-Psychopharmacology and Biological Psychiatry , 1984

Record 2

Clinical / human literature PubMed record PMID 6548969

Official Source

Effects of DSIP in man. Multifunctional psychophysiological effects

Schneider-Helmert et al. . Neuropeptides , 1983

Record 3

Clinical / human literature PubMed record PMID 6689058

Official Source